Gene

phdh-1

Species
Caenorhabditis elegans
Symbol
phdh-1
Name
PHosphoglycerate DeHydrogenase (PHGDH) 1
Synonyms
  • C31C9.2
  • CELE_C31C9.2
Biotype
protein coding gene
Automated Description
Predicted to enable phosphoglycerate dehydrogenase activity. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Neu-Laxova syndrome 1; PHGDH deficiency; and amino acid metabolic disorder. Orthologous to human PHGDH (phosphoglycerate dehydrogenase).
WB Description
C31C9.2 is orthologous to the human gene PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH; OMIM:606879), which when mutated leads to phosphoglycerate dehydrogenase deficiency.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42938
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.6370M13.6372M13.6374M13.6376M13.6378M13.6380M13.6382M13.6384M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions