Gene

ttll-5

Species
Caenorhabditis elegans
Symbol
ttll-5
Name
Tubulin Tyrosine Ligase Like 5
Synonyms
  • C55A6.2
  • CELE_C55A6.2
Biotype
protein coding gene
Automated Description
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in response to hermaphrodite contact. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5).
WB Description
ttll-5 encodes a putative tubulin polyglutamylase orthologous to humanTTLL5; TTLL-5 is required for embryonic development and fertility; byorthology, TTLL-5 is expected to initiate glutamylchains rather than elongating them, to prefer alpha-tubulin overbeta-tubulin as a substrate, and to have non-tubulin substrates.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12241
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.5095M11.5100M11.5105M11.5110M11.5115M11.5120M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions