Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in response to hermaphrodite contact. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5).
WB Description
ttll-5 encodes a putative tubulin polyglutamylase orthologous to humanTTLL5; TTLL-5 is required for embryonic development and fertility; byorthology, TTLL-5 is expected to initiate glutamylchains rather than elongating them, to prefer alpha-tubulin overbeta-tubulin as a substrate, and to have non-tubulin substrates.