Predicted to enable oxidoreductase activity. Predicted to be involved in fatty acid elongation. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12).
WB Description
stdh-2 encodes a putative steroid dehydrogenase required for normally short lifespan; STDH-2 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767, STDH-1, and STDH-3/-4.