Gene

hxk-1

Species
Caenorhabditis elegans
Symbol
hxk-1
Name
HeXoKinase homolog 1
Synonyms
  • CELE_F14B4.2
  • F14B4.2
Biotype
protein coding gene
Automated Description
Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in several processes, including glucose 6-phosphate metabolic process; glycolytic process; and intracellular glucose homeostasis. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 4G; anemia (multiple); artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Orthologous to several human genes including GCK (glucokinase).
WB Description
Predicted to enable fructokinase activity and glucokinase activity. Predicted to be involved in carbohydrate metabolic process; glucose 6-phosphate metabolic process; and intracellular glucose homeostasis. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glucose metabolism disease (multiple); and hematologic cancer (multiple). Is an ortholog of human GCK (glucokinase).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19443
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.272M9.273M9.274M9.275M9.276M9.277M9.278M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            hxk-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              hxk-1 role
              hxk-1 genetic perturbation
              Interactor gene
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