Version: 8.0.0Date: Tue Jan 28 2025
Gene
mboa-7
- Species
- Caenorhabditis elegans
- Symbol
- mboa-7
- Name
- Membrane Bound O-Acyl transferase, MBOAT 7
- Synonyms
- CELE_F14F3.3
- F14F3.3
- Biotype
- protein coding gene
- Automated Description
- Enables O-acyltransferase activity. Involved in egg-laying behavior; nematode larval development; and phosphatidylinositol biosynthetic process. Located in intracellular membrane-bounded organelle. Is expressed in body wall musculature; hermaphrodite gonad; intestine; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7).
- WB Description
- mboa-7 encodes a lysophosphatidylinositol (LPI)-specific acyltransferase which acts on the sn-2 hydroxyl of glycerol (sn-2 LPIAT); MBOA-7 is required in vivo for the incorporation of externally supplemented polyunsaturated fatty acids (PUFAs) into the sn-2 position of phosphatidylinositol (PI), as well as for most LPIAT activity in microsomes, progression through larval development, normal egg-laying, and (with FAT-1 and FAT-4) normally rapid growth at low temperature; membrane vesicles expressing MBOA-7 or its human ortholog show elevated LPIAT activity; mboa-7 is expressed ubiquitously, throughout development from embryogenesis to adulthood, with high expression in pharyngeal muscles, body wall muscles, vulval cells, distal tip cells, intestinal cells, and adult spermatheca; residue H350 of MBOA-7 is essential for its biochemical activity in membrane vesicles; mboa-7 mutants have abnormally low levels of eicosapentaenoic acid (EPA) in the sn-2 position of PI, and fail to have their growth rescued by supplementary arachidonic acid (AA) or EPA in their diet.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13906
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:10521806...10524565 - (2.76 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.