Version: 8.0.0
Date: Tue Jan 28 2025
tbcd-1
Caenorhabditis elegansWB:WBGene00008887
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

tbcd-1

Species
Caenorhabditis elegans
Symbol
tbcd-1
Name
TuBulin folding Cofactor D homolog 1
Synonyms
  • CELE_F16D3.4
  • F16D3.4
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activator activity and beta-tubulin binding activity. Involved in microtubule cytoskeleton organization. Predicted to be located in microtubule. Predicted to be active in lateral plasma membrane. Is expressed in intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in early onset progressive encephalopathy with brain atrophy and thin corpus callosum. Orthologous to human TBCD (tubulin folding cofactor D).
WB Description
F16D3.4 encodes a putative beta-tubulin folding cofactor D, orthologous to human TBCD (OMIM:604649); in early embryos, F16D3.4 is required for normally rapid microtubule elongation; F16D3.4 may be a ligand and effector of the ARL2 ortholog EVL-20; F16D3.4 is expressed in larval and adult pharynx, intestine, and neurons; in mass RNAi assays, F16D3.4 is required for normal mitotic spindle elongation, embryonic and larval viability, fertility, locomotion, body shape, vulval development, and cuticular integrity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12658
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            8.3640M8.3645M8.3650M8.3655M8.3660M8.3665M8.3670M8.3675M8.3680M8.3685M8.3690M8.3695M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            tbcd-1 molecule type
            Interactor gene
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              Genetic Interactions

              tbcd-1 role
              tbcd-1 genetic perturbation
              Interactor gene
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