Version: 8.0.0
Date: Tue Jan 28 2025
ndk-1
Caenorhabditis elegansWB:WBGene00009119
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ndk-1

Species
Caenorhabditis elegans
Symbol
ndk-1
Name
Nucleoside Diphosphate Kinase 1
Synonyms
  • CELE_F25H2.5
  • F25H2.5
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and protein histidine kinase activity. Involved in several processes, including negative regulation of axon regeneration; positive regulation of vulval development; and regulation of engulfment of apoptotic cell. Is expressed in several structures, including excretory cell; hypodermis; intestine; nervous system; and non-striated muscle. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Orthologous to several human genes including NME2 (NME/NM23 nucleoside diphosphate kinase 2); NME1-NME2 (NME1-NME2 readthrough); and NME2P1 (NME2 pseudogene 1).
WB Description
Enables identical protein binding activity and protein histidine kinase activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of vulval development; and regulation of cellular component organization. Expressed in head. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); prostatic hypertrophy; and teratoma. Is an ortholog of human NME1-NME2 (NME1-NME2 readthrough); NME2 (NME/NM23 nucleoside diphosphate kinase 2); and NME2P1 (NME2 pseudogene 1).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11349
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ndk-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            ndk-1 role
            ndk-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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