Version: 8.0.0Date: Tue Jan 28 2025
Gene
dep-1
- Species
- Caenorhabditis elegans
- Symbol
- dep-1
- Name
- EP (Density-Enhanced Phosphatase) homolog 1
- Synonyms
- CELE_F44G4.8
- F44G4.8
- Biotype
- protein coding gene
- Automated Description
- Enables phosphatase activity. Involved in positive regulation of vulval development; protein dephosphorylation; and vulval cell fate specification. Predicted to be located in membrane. Is expressed in several structures, including P5.p hermaphrodite; P5.ppp; P6.p hermaphrodite; P7.p hermaphrodite; and P7.paa. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B).
- WB Description
- dep-1 encodes a class III receptor protein tyrosine phosphatase (R-PTP)orthologous to human R-PTPs such as PTPRJ/Dep-1 (mutated in epithelialcancers; OMIM:600925); DEP-1 is required, redundantly with LIP-1 andLET-60, and downstream of LIN-12, to promote secondary over primary vulvalfate in the P5.p and P7.p lineages; DEP-1 is expressed in P5.p and P7.plineages, and dep-1 acts cell-autonomously in these lineages; DEP-1colocalizes with LET-23 in punctae, and binds LET-23 in vitro; DEP-1, withLIP-1, is also required for normal duct cell and excretory poredevelopment; dep-1 mutations are wild-type in isolation, but have vulvalphenotypes with added mutations in lin-15, lip-1, or let-60; DEP-1laterally inhibits secondary vulval fates in parallel with LIN-12/Notchsignalling; in primary (P5.p) vulval cells, LET-60/RAS-activated SUR-2inhibits dep-1 and lin-12 expression; since RNAi of 125 out of 165predicted C. elegans protein phosphatase genes fails to enhance lip-1mutations, the LIP-1/DEP-1 interaction is likely to be highly specific.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR19134
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrII:9005796...9019798 - (14.00 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.