Enables RNA polymerase II complex binding activity. Involved in transcription initiation at RNA polymerase II promoter. Part of transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2).
WB Description
F54D5.11 encodes the C. elegans ortholog of the TFIIE beta subunit; when expressed in vitro with the TFIIE alpha subunit encoded by ZK550.4, the protein product of F54D5.11 supports transcription initiation; the protein products of F54D5.11 and ZK550.4 physically interact in vitro.