Gene

dot-1.2

Species
Caenorhabditis elegans
Symbol
dot-1.2
Name
DOT1 histone methyltransferase family 1.2
Synonyms
  • CELE_F54F7.7
  • F54F7.7
Biotype
protein coding gene
Automated Description
Predicted to enable histone H3K79 methyltransferase activity. Predicted to be involved in DNA damage checkpoint signaling; DNA repair; and subtelomeric heterochromatin formation. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
WB Description
Predicted to enable histone H3K79 methyltransferase activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Is an ortholog of human DOT1L (DOT1 like histone lysine methyltransferase).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21451
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
11.8680M11.8682M11.8684M11.8686M11.8688M11.8690M11.8692M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions