Version: 8.0.0
Date: Tue Jan 28 2025
magi-1
Caenorhabditis elegansWB:WBGene00010444
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

magi-1

Species
Caenorhabditis elegans
Symbol
magi-1
Name
MAGI (Membrane Associated Guanylate kinase Inverted) homolog 1
Synonyms
  • CELE_K01A6.2
  • K01A6.2
Biotype
protein coding gene
Automated Description
Enables beta-catenin binding activity and glutamate receptor binding activity. Involved in habituation; long-term memory; and regulation of protein localization. Located in adherens junction and synapse. Is expressed in several structures, including anus; egg-laying apparatus; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to several human genes including MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3).
WB Description
magi-1 encodes a multi PDZ-domain containing tight junction-associated protein: MAGIs are members of vertebrate membrane associated guanylate-kinase (MAGUK) family (OMIM: 602625); MAGI-1/S-SCAM is also a broadly conserved synaptic scaffolding molecule; MAGI-1 is a component of a protein complex that functions as an organizer which maintains special segregation of different adhesion complexes into distinct lateral membrane domains; in magi-1 mutants spatial separation between DAC and CCC complexes gets disrupted resulting in loss of compartmentalization and reduced strength of the epithelial cell adhesion in embryos; MAGI-1 is required for regulating synaptic plasticity by setting up different junctional compartments at newly forming cell junctions and by modulating synaptic structures: MAGI-1 plays a role in consolidation of changes in synapse structure during associative learning by organizing localization of synaptic adhesion molecules; MAGI-1 localizes to epithelial junction via its third PDZ domain, accumulates at the leading edge of migrating cells during ventral enclosure; antibody staining reveals that MAGI-1 localizes in a distinct band apical to the CCC and DAC protein complexes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10316
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            11.716M11.718M11.720M11.722M11.724M11.726M11.728M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            magi-1 molecule type
            Interactor gene
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              Genetic Interactions

              magi-1 role
              magi-1 genetic perturbation
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