Version: 8.0.0Date: Tue Jan 28 2025
Gene
rack-1
- Species
- Caenorhabditis elegans
- Symbol
- rack-1
- Name
- RACK1 (mammalian Receptor of Activated C Kinase) homolog 1
- Synonyms
- CELE_K04D7.1
- K04D7.1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable protein kinase C binding activity and ribosome binding activity. Involved in several processes, including antifungal innate immune response; cytoskeleton-dependent cytokinesis; and motor neuron axon guidance. Located in several cellular components, including centrosome; growth cone; and kinetochore. Is expressed in anterior distal tip cell; neurons; and posterior distal tip cell. Orthologous to human RACK1 (receptor for activated C kinase 1).
- WB Description
- rack-1 encodes a seven-WD repeat-containing protein that is the C. elegans ortholog of vertebrate Receptor for Activated C Kinase (Rack1); rack-1 is required cell autonomously for VD/DD motor axon pathfinding; rack-1 is also required for gonadal distal tip cell migration and for normal brood sizes; genetic analyses indicate that rack-1 functions in the same pathway with ced-10/Rac and unc-115/abLIM, and in parallel to mig-2/RhoG and unc-34/Enabled, to control axon pathfinding; in regulating axon pathfinding, RACK-1 likely acts upstream of UNC-115 with which it physically interacts; rack-1 also acts downstream of, or with, unc-115 to regulate P cell nuclear migration; in regulating gonadal distal tip cell migration, rack-1 acts either independently of, or in the same pathway as, ced-10 and mig-2; rack-1::gfp is expressed in most, if not all, tissues, and a RACK-1::GFP localizes to the cytoplasm, with some fusion protein also seen in the axons, cell bodies, and growth cones of migrating VD neurons.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR19868
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
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Sequence Feature Viewer
- Genome location
- ChrIV:10176680...10178099 + (1.42 kb)
- Assembly version
- WBcel235
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Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.