Gene

ymel-1

Species
Caenorhabditis elegans
Symbol
ymel-1
Name
YME1-Like (Yeast Mitochondrial Escape) AAA protease 1
Synonyms
  • CELE_M03C11.5
  • M03C11.5
Biotype
protein coding gene
Automated Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be located in mitochondrial inner membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase).
WB Description
ymel-1 encodes an ortholog of human YME1L1 (OMIM:607472) and budding yeast Yme1p; YMEL-1 can suppress the formation of alpha-synuclein inclusions in older adults; on the basis of orthology, YMEL-1 is predicted to be an AAA protease of the mitochondrial inner membrane; however, YMEL-1 has no obvious function in mass RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43655
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
10.4165M10.4170M10.4175M10.4180M10.4185M10.4190M10.4195M10.4200M10.4205M10.4210M10.4215M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions