Gene

glo-1

Species
Caenorhabditis elegans
Symbol
glo-1
Name
Gut granule LOss 1
Synonyms
  • CELE_R07B1.12
  • R07B1.12
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activity. Involved in lipid storage and lysosome organization. Located in gut granule membrane. Is expressed in intestine. Orthologous to several human genes including RAB32 (RAB32, member RAS oncogene family).
WB Description
glo-1 encodes a member of the Rab family of small GTPases that is similar to the vertebrate Rab32 and Rab38 proteins and Drosophila Rab-RP1/Lightoid; throughout development, glo-1 activity is required for biogenesis of the lysosome-related gut granules; in addition, glo-1 activity is required during embryonic development for normal body morphogenesis; in regulating gut granule formation, glo-1 acts downstream of apb-3 which encodes the AP-3 complex beta subunits; GLO-1 reporter fusions and antibodies indicate that GLO-1 is expressed in embryonic and adult intestinal cells, beginning at the E2 stage of intestinal development; within intestinal cells, GLO-1 colocalizes with lysosome-related gut granules.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24073
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.873M9.874M9.875M9.876M9.877M9.878M9.879M9.880M9.881M9.882M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            glo-1 molecule type
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              Genetic Interactions

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