Version: 8.0.0
Date: Tue Jan 28 2025
glo-1
Caenorhabditis elegansWB:WBGene00011083
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

glo-1

Species
Caenorhabditis elegans
Symbol
glo-1
Name
Gut granule LOss 1
Synonyms
  • CELE_R07B1.12
  • R07B1.12
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activity. Involved in lipid storage and lysosome organization. Located in gut granule membrane. Is expressed in intestine. Orthologous to several human genes including RAB32 (RAB32, member RAS oncogene family).
WB Description
glo-1 encodes a member of the Rab family of small GTPases that is similar to the vertebrate Rab32 and Rab38 proteins and Drosophila Rab-RP1/Lightoid; throughout development, glo-1 activity is required for biogenesis of the lysosome-related gut granules; in addition, glo-1 activity is required during embryonic development for normal body morphogenesis; in regulating gut granule formation, glo-1 acts downstream of apb-3 which encodes the AP-3 complex beta subunits; GLO-1 reporter fusions and antibodies indicate that GLO-1 is expressed in embryonic and adult intestinal cells, beginning at the E2 stage of intestinal development; within intestinal cells, GLO-1 colocalizes with lysosome-related gut granules.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24073
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            9.873M9.874M9.875M9.876M9.877M9.878M9.879M9.880M9.881M9.882M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            glo-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              glo-1 role
              glo-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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