Version: 8.0.0
Date: Tue Jan 28 2025
aldo-1
Caenorhabditis elegansWB:WBGene00011474
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

aldo-1

Species
Caenorhabditis elegans
Symbol
aldo-1
Name
ALDOlase (fructose bisphosphate aldolase) 1
Synonyms
  • CELE_T05D4.1
  • T05D4.1
Biotype
protein coding gene
Automated Description
Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; hereditary fructose intolerance syndrome; and type 2 diabetes mellitus. Orthologous to several human genes including ALDOA (aldolase, fructose-bisphosphate A) and ALDOC (aldolase, fructose-bisphosphate C).
WB Description
aldo-1 is orthologous to the human gene ALDOLASE A, FRUCTOSE-BISPHOSPHATE (ALDOA; OMIM:103850), which when mutated leads to aldolase A deficiency.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11627
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          aldo-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            aldo-1 role
            aldo-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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