Species

Caenorhabditis elegans

Symbol

cgt-1

Name

Ceramide Glucosyl Transferase 1

Synonyms

CELE_T06C12.10
T06C12.10

Biotype

protein coding gene

Automated Description

Predicted to enable ceramide glucosyltransferase activity. Involved in glucosylceramide biosynthetic process; nematode larval development; and regulation of protein localization to basolateral plasma membrane. Predicted to be active in membrane. Is expressed in excretory system; intestine; pharyngeal muscle cell; pharyngeal-intestinal valve; and rectum. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase).

WB Description

cgt-1 encodes a transmembrane protein that is one of three C. elegans ceramide glucosyltransferases; by homology, CGT-1 is predicted to localize to the Golgi membrane and catalyze the transfer of glucose from UDP-glucose to ceramide to synthesize glucosylceramide, a glycosphingolipid precursor; although cgt-1 mutant worms show no obvious defects, animals doubly mutant for cgt-1 and cgt-3 arrest development in the early L1 larval stage, showing impaired feeding ability; in addition, cgt-3;cgt-1 and cgt-3;cgt-1;cgt-2 mutant animals show reduced glucosylceramide levels; a CGT-1::GFP reporter fusion is expressed in pharyngeal tissues, the intestine, the pharyngeal-intestinal and intestinal-rectal valves, the rectal gland cells, unidentified head cells, and the excretory system; cgt-1 expression in the intestine is sufficient to rescue the defects of cgt-3;cgt-1 mutant animals.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR12726

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Paralogy

Function - GO Annotations

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Pathways

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Phenotypes

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Other Sources: None

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Disease Associations

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

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Models

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Sequence Feature Viewer

Genome location

ChrV:15886719...15888851 - (2.13 kb)

Assembly version

WBcel235

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

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Molecular Interactions

cgt-1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

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