Gene

ddx-19

Species
Caenorhabditis elegans
Symbol
ddx-19
Name
DEAD boX helicase homolog 19
Synonyms
  • CELE_T07D4.4
  • T07D4.4
Biotype
protein coding gene
Automated Description
Predicted to enable RNA helicase activity and mRNA binding activity. Involved in germ cell development. Located in P granule. Is expressed in excretory cell; hypodermis; and tail. Orthologous to several human genes including DDX19A (DEAD-box helicase 19A) and DDX19B (DEAD-box helicase 19B).
WB Description
ddx-19 encodes a DEAD-box helicase; ddx-19(RNAi) in a mpk-1(ga111ts) mutant background results in germline developmental defects, including disruption of membrane organization in pachytene cells and disorganized oocytes; DDX-19 can be phosphorylated by murine ERK2 in vitro, suggesting that it is a substrate for the RTK-RAS-ERK pathway in vivo; consistent with this, DDX-19 phosphorylation is absent in mpk-1 mutant animals; DDX-19 localizes to perinuclear P granules.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47958
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.8850M8.8855M8.8860M8.8865M8.8870M8.8875M8.8880M8.8885M8.8890M8.8895M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ddx-19 molecule type
            Interactor gene
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              Genetic Interactions

              ddx-19 role
              ddx-19 genetic perturbation
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