Gene

chc-1

Species
Caenorhabditis elegans
Symbol
chc-1
Name
Clathrin Heavy Chain 1
Synonyms
  • CELE_T20G5.1
  • clhc-1
Biotype
protein coding gene
Automated Description
Predicted to enable clathrin light chain binding activity. Involved in several processes, including apical protein localization; determination of adult lifespan; and positive regulation of clathrin-dependent endocytosis. Located in several cellular components, including apical plasma membrane; clathrin-coated endocytic vesicle; and mitotic spindle. Is expressed in coelomocyte; germ line; hypodermal cell; intestine; and pharyngeal cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1).
WB Description
chc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10292
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            10.204M10.205M10.206M10.207M10.208M10.209M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            chc-1 molecule type
            Interactor gene
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              Genetic Interactions

              chc-1 role
              chc-1 genetic perturbation
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