Version: 8.0.0
Date: Tue Jan 28 2025
pash-1
Caenorhabditis elegansWB:WBGene00011908
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

pash-1

Species
Caenorhabditis elegans
Symbol
pash-1
Name
PArtner of DroSHa (DRSH-1 interactor) 1
Synonyms
  • CELE_T22A3.5
  • T22A3.5
Biotype
protein coding gene
Automated Description
Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in several processes, including primary miRNA processing; regulation of epidermal cell differentiation; and regulation of vulval development. Predicted to be part of microprocessor complex. Is expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit).
WB Description
pash-1 encodes an RNA-binding protein that is orthologous to Drosophila Pasha and mammalian DGCR8; pash-1 activity is required for processing of primary miRNA transripts (pri-miRNAs), such as that of let-7, to generate pre-miRNAs that will then be processed by DCR-1 to generate mature miRNAs; accordingly, pash-1 mutants show defects in let-7-mediated developmental processes, namely the transition from late larval to adult cell fates.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13482
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            10.599M10.600M10.601M10.602M10.603M10.604M10.605M10.606M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pash-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              pash-1 role
              pash-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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