Version: 8.0.0
Date: Tue Jan 28 2025
gpdh-3
Caenorhabditis elegansWB:WBGene00012031
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

gpdh-3

Species
Caenorhabditis elegans
Symbol
gpdh-3
Name
Glycerol-3-Phosphate DeHydrogenase 3
Synonyms
  • CELE_T25G3.4
  • T25G3.4
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol catabolic process and glycerol-3-phosphate metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2).
WB Description
T25G3.4 encodes a putative mitochondrial glycerol-3-phosphatedehydrogenase, paralogous to Y50E8A.6 and orthologous to human GPD2(OMIM:138430, mutated in type II diabetes mellitus); T25G3.4 transcriptsare not obviously enriched during oogenesis, but T25G3.4 is predicted tobe coexpressed in an operon with chs-1 and T25G3.3; such coexpression,if real, may simply reflect all three genes being required foroogenesis, rather than some more detailed functional connection; T25G3.4has no obvious function in mass RNAi assays.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11985
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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        Experimental condition
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          gpdh-3 molecule type
          Interactor gene
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            Genetic Interactions

            gpdh-3 role
            gpdh-3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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