Species

Caenorhabditis elegans

Symbol

W01F3.2

Name

Not Available

Synonyms

CELE_W01F3.2

Biotype

protein coding gene

Automated Description

Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human MMP2 (matrix metallopeptidase 2); MMP23B (matrix metallopeptidase 23B); and MMP9 (matrix metallopeptidase 9).

WB Description

Enriched in AIB; SIB; germline precursor cell; and hypodermis based on tiling array and single-cell RNA-seq studies. Is affected by several genes including cyc-1; hyl-2; and hyl-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by twenty-two chemicals including 1-methylnicotinamide; manganese chloride; and sodium arsenite based on RNA-seq; microarray; and proteomic studies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and carcinoma (multiple). Is predicted to encode a protein with the following domain: Hemopexin-like domain superfamily. Is an ortholog of human MMP2 (matrix metallopeptidase 2); MMP23B (matrix metallopeptidase 23B); and MMP9 (matrix metallopeptidase 9). Human MMP9 enables identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity.

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR10201

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources: None
Other Sources: None

Phenotype Term	Annotation details	References
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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

ChrV:20660325...20662037 + (1.71 kb)

Assembly version

WBcel235

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Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

W01F3.2 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

W01F3.2 role	W01F3.2 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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