Gene

rabx-5

Species
Caenorhabditis elegans
Symbol
rabx-5
Name
RAB eXchange factor 5
Synonyms
  • CELE_Y39A1A.5
  • Y39A1A.5
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosomal vesicle fusion and molting cycle. Located in early endosome. Is expressed in several structures, including coelomocyte; distal tip cell; neurons; ventral nerve cord; and vulva. Orthologous to human RABGEF1 (RAB guanine nucleotide exchange factor 1).
WB Description
rabx-5 encodes a protein containing a zinc-finger domain and a Vps9 domain that is the C. elegans ortholog of the Rabex-5 Rab5 guanine-nucleotide exchange factor (GEF); RABX-5 activity is required for homotypic endosomal fusion, and genetic studies indicate that rabx-5 functions redundantly with rme-6 to regulate RAB-5 localization to endosomes and, more generally, nematode larval development, particularly with respect to regulation of the molting cycle; RABX-5 physically interacts with RABN-5, the C. elegans ortholog of Rabaptin-5, a Rab5 effector protein and with the RAB-5 GTPase (likely the GDP-bound form).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23101
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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10.606M10.607M10.608M10.609M10.610M10.611M10.612M10.613M10.614M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions