Version: 8.0.0
Date: Tue Jan 28 2025
zhp-4
Caenorhabditis elegansWB:WBGene00012678
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

zhp-4

Species
Caenorhabditis elegans
Symbol
zhp-4
Name
Zip (yeast meiotic zipper) Homologous Protein 4
Synonyms
  • CELE_Y39B6A.16
  • Y39B6A.16
Biotype
protein coding gene
Automated Description
Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis. Predicted to be located in chromosome. Predicted to be active in synaptonemal complex. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to human RNF212 (ring finger protein 212).
WB Description
Y39B6A.16 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); Y39B6A.16 is required in mass RNAi assays for embryonic viability; Y39B6A.16 is paralogous to ZHP-3, D1081.9, and F55A12.10.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22663
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            19.0995M19.1000M19.1005M19.1010M19.1015M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            zhp-4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              zhp-4 role
              zhp-4 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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