Gene

Y39B6A.33

Species
Caenorhabditis elegans
Symbol
Y39B6A.33
Name
Ribosome biogenesis protein NOP53
Synonyms
  • CELE_Y39B6A.33
  • Y39B6.33
Biotype
protein coding gene
Automated Description
Predicted to enable 5S rRNA binding activity. Involved in positive regulation of cellular respiration. Located in nucleolus. Orthologous to human NOP53 (NOP53 ribosome biogenesis factor).
WB Description
Y39B6A.33 encodes the C. elegans ortholog of mammalian GLTSCR2/PICT1 (GLioma Tumor Suppressor Candidate Region gene 2/Protein Interacting with the C Terminus-1); loss of Y39B6A.33 activity via RNAi results in lower oxygen consumption rates, suggesting that Y39B6A.33 plays a role in positively regulating mitochondrial respiration rates; in body wall muscle cells, Y39B6A.33 localizes to the nucleolus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14211
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
19.0020M19.0025M19.0030M19.0035M19.0040M19.0045M19.0050M19.0055M19.0060M19.0065M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions