Version: 8.0.0
Date: Tue Jan 28 2025
sptf-3
Caenorhabditis elegansWB:WBGene00012735
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

sptf-3

Species
Caenorhabditis elegans
Symbol
sptf-3
Name
SP (Specificity Protein) Transcription Factor 3
Synonyms
  • CELE_Y40B1A.4
  • Y40B1A.4
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and chromatin binding activity. Involved in several processes, including generation of neurons; nematode larval development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including MSpaa; hypodermal cell; intestine; pharyngeal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP1 (Sp1 transcription factor); SP3 (Sp3 transcription factor); and SP4 (Sp4 transcription factor).
WB Description
sptf-3 encodes a C2H2 zinc finger domain-containing protein that is a member of the Sp1 family of transcription factors; SPTF-3 activity is required for caspase-dependent and -independent apoptotic cell death of the sisters of two cells: the M4 pharyngeal motor neuron and the AQR sensory neuron; in addition, SPTF-3 plays a role in cell fate specification, embryonic and larval development, and morphogenesis; SPTF-3 regulates apoptosis through transcriptional control of the pro-apoptotic gene egl-1 and of pig-1, which encodes a protein related to AMP-activated protein kinases; an SPTF-3::GFP promoter fusion is expressed ubiquitously in embryos and early larvae, and localizes to the nucleus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23235
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            13.361M13.362M13.363M13.364M13.365M13.366M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            sptf-3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              sptf-3 role
              sptf-3 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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