Gene

Y48B6A.1

Species
Caenorhabditis elegans
Symbol
Y48B6A.1
Name
Ribosome biogenesis protein BOP1 homolog
Synonyms
  • CELE_Y48B6A.1
Biotype
protein coding gene
Automated Description
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor).
WB Description
Y48B6A.1 encodes an ortholog of human BOP1 (OMIM:610596, overexpressed in colon cancer) and S. cerevisiae ERB1; Y48B6A.1 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation; like PRO-1, -2, and -3, Y48B6A.1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germ line; however, BOP1 is also a phosphoprotein in mitotic spindles and required for normal chromosomal segregation, raising the possibility that Y48B6A.1 is multifunctional.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR17605
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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14.1515M14.1520M14.1525M14.1530M14.1535M14.1540M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions