Version: 8.0.0
Date: Tue Jan 28 2025
vha-13
Caenorhabditis elegansWB:WBGene00013025
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

vha-13

Species
Caenorhabditis elegans
Symbol
vha-13
Name
Vacuolar H ATPase 13
Synonyms
  • CELE_Y49A3A.2
  • phi-51
Biotype
protein coding gene
Automated Description
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in lysosomal lumen acidification. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Is expressed in body wall musculature; excretory cell; head; and intestine. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A).
WB Description
vha-13 encodes an ortholog of subunit A of the cytoplasmic (V1) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-13 is predictedto hydrolyse ATP as part of a cytosolic VHA-12/VHA-13 heterohexamer,whose activity drives the V-ATPase rotor; VHA-13 levels are lowered inmutants with either abnormally low or abnormally high calcineurinlevels, and elevated in mutants lacking both calcineurin andcalreticulin; VHA-13 is dispensable for alae formation, like the V1subunit VHA-8, but not like the V0 subunits VHA-1 and VHA-4.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43607
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            14.3520M14.3525M14.3530M14.3535M14.3540M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vha-13 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              vha-13 role
              vha-13 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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