Predicted to enable metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including hypodermis; intestine; pharynx; spermatheca; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to several human genes including ING3 (inhibitor of growth family member 3).
WB Description
ing-3 encodes a plant homeodomain-containing protein closely related to human ING3 (Inhibitor of Growth 3, OMIM:607493), mutations in which have been associated with head and neck cancers; genetic analysis indicates that, in the germline, ING-3 functions with CEP-1/p53 to effect germ cell apoptosis in response to gamma irradiation; in addition, ING-3 activity also appears to be required for fully normal locomotion; ING-3 is widely expressed from embryogenesis through adulthood and co-localizes with chromatin in both germ cells and somatic tissues.