Gene

ing-3

Species
Caenorhabditis elegans
Symbol
ing-3
Name
ING (mammalian INhibitor of Growth) homolog 3
Synonyms
  • CELE_Y51H1A.4
  • Y51H1A.4
Biotype
protein coding gene
Automated Description
Predicted to enable metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including hypodermis; intestine; pharynx; spermatheca; and vulva. Used to study cancer. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to several human genes including ING3 (inhibitor of growth family member 3).
WB Description
ing-3 encodes a plant homeodomain-containing protein closely related to human ING3 (Inhibitor of Growth 3, OMIM:607493), mutations in which have been associated with head and neck cancers; genetic analysis indicates that, in the germline, ING-3 functions with CEP-1/p53 to effect germ cell apoptosis in response to gamma irradiation; in addition, ING-3 activity also appears to be required for fully normal locomotion; ING-3 is widely expressed from embryogenesis through adulthood and co-localizes with chromatin in both germ cells and somatic tissues.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10333
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
13.877M13.878M13.879M13.880M13.881M13.882M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions