Gene

efa-6

Species
Caenorhabditis elegans
Symbol
efa-6
Name
Exchange Factor for Arf 6
Synonyms
  • CELE_Y55D9A.1
  • Y55D9A.1
Biotype
protein coding gene
Automated Description
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including mitotic nuclear membrane disassembly; negative regulation of axon extension involved in regeneration; and regulation of cell cycle process. Located in cell cortex; microtubule minus-end; and plasma membrane. Is expressed in U.la; U.lp; and linker cell. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing).
WB Description
efa-6 encodes a putative guanine nucleotide exchange factor that inhibits DHC-1 in vivo; EFA-6's human orthologs are the pleckstrin and Sec7 domain proteins PSD/TYL/cytohesin-1 (OMIM:602327), PSD2, PSD3, and PSD4; efa-6(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that EFA-6 negatively regulates dynein; EFA-6 is localized to nonpolarized cell cortex in oocytes and early one-cell zygotes, to anterior cell cortex in one-cell embryos after pseudocleavage, and to the interface of AB and P1 blastomeres, subsequently disappearing in four-cell embryos; EFA-6 has a central Sec7 domain predicted to activate guanine-nucleotide exchange in ARF1, and a C-terminal pleckstrin-homology domain predicted to activate the Sec7 domain when binding phosphatidylinositol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10663
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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12.606M12.607M12.608M12.609M12.610M12.611M12.612M12.613M12.614M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions