Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including mitotic nuclear membrane disassembly; negative regulation of axon extension involved in regeneration; and regulation of cell cycle process. Located in cell cortex; microtubule minus-end; and plasma membrane. Is expressed in U.la; U.lp; and linker cell. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing).
WB Description
efa-6 encodes a putative guanine nucleotide exchange factor that inhibits DHC-1 in vivo; EFA-6's human orthologs are the pleckstrin and Sec7 domain proteins PSD/TYL/cytohesin-1 (OMIM:602327), PSD2, PSD3, and PSD4; efa-6(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that EFA-6 negatively regulates dynein; EFA-6 is localized to nonpolarized cell cortex in oocytes and early one-cell zygotes, to anterior cell cortex in one-cell embryos after pseudocleavage, and to the interface of AB and P1 blastomeres, subsequently disappearing in four-cell embryos; EFA-6 has a central Sec7 domain predicted to activate guanine-nucleotide exchange in ARF1, and a C-terminal pleckstrin-homology domain predicted to activate the Sec7 domain when binding phosphatidylinositol.