Gene

sec-61.A

Species
Caenorhabditis elegans
Symbol
sec-61.A
Name
yeast SEC homolog 61.A
Synonyms
  • CELE_Y57G11C.15
  • sec-61
Biotype
protein coding gene
Automated Description
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2).
WB Description
Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Is an ortholog of human SEC61A1 (SEC61 translocon subunit alpha 1) and SEC61A2 (SEC61 translocon subunit alpha 2).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10906
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
14.8230M14.8235M14.8240M14.8245M14.8250M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions