Version: 8.0.0Date: Tue Jan 28 2025
Gene
hhat-2
- Species
- Caenorhabditis elegans
- Symbol
- hhat-2
- Name
- Homolog of Hedgehog AcylTransferase 2
- Synonyms
- CELE_Y57G11C.17
- Y57G11C.17
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable palmitoyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to human HHAT (hedgehog acyltransferase).
- WB Description
- hhat-2 encodes a putative protein-cysteine N-palmitoyltransferase ('hedgehog acyltransferase') orthologous to human HHAT (OMIM: 605743) and GUP1 (HHATL; OMIM:608116), and paralogous to HHAT-1; HHAT-2 is required for normal larval development and fat accumulation in mass RNAi assays; however, because C. elegans has no HEDGEHOG homolog, the substrate and function of HHAT-2 in vivo are unclear.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR13285
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
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Sequence Feature Viewer
- Genome location
- ChrIV:14826428...14829126 - (2.70 kb)
- Assembly version
- WBcel235
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