Version: 8.0.0
Date: Tue Jan 28 2025
zoo-1
Caenorhabditis elegansWB:WBGene00013683
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

zoo-1

Species
Caenorhabditis elegans
Symbol
zoo-1
Name
ZO-1 (Zonula Occludens tight junctional protein) Ortholog 1
Synonyms
  • CELE_Y105E8A.26
  • tag-301
Biotype
protein coding gene
Automated Description
Predicted to enable cell adhesion molecule binding activity. Involved in actin filament organization; embryo development; and embryonic morphogenesis. Located in adherens junction and bicellular tight junction. Is expressed in muscle cell. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to several human genes including TJP2 (tight junction protein 2).
WB Description
zoo-1 encodes a protein ortholog of the zonula occludens (ZO) subfamily of membrane-associated guanylate kinases (MAGUKs); zoo-1 is involved in the recruitment of actin to cell junctions in a hmr-1/cadherin dependant manner; genetic interaction studies indicate that zoo-1 acts together with hmp-1/alpha-catenin and hmp-2/beta-catenin for the proper organization of actin at epidermal junctions during epthelial morphogenesis; consistant with these roles, zoo-1 expression is enriched at epidermal cell borders; zoo-1 is also expressed in myoblasts and mature muscle cells.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13865
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            14.530M14.532M14.534M14.536M14.538M14.540M14.542M14.544M14.546M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            zoo-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              zoo-1 role
              zoo-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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