Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in labial sensillum and nervous system. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG1 (protein kinase AMP-activated non-catalytic subunit gamma 1); PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2); and PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3).
WB Description
aakg-1 is orthologous to the human gene AMP-ACTIVATED PROTEIN KINASE GAMMA SUBUNIT (PRKAG2; OMIM:602743), which when mutated leads to disease; aakg-1 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.