Gene

fbxl-1

Species
Caenorhabditis elegans
Symbol
fbxl-1
Name
F BoX Leucine rich repeat containing protein homolog 1
Synonyms
  • C02F5.7
  • CELE_C02F5.7
Biotype
protein coding gene
Automated Description
Involved in several processes, including dauer entry; defecation rhythm; and regulation of defecation rhythm. Located in several cellular components, including axon; dendrite; and perikaryon. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2) and FBXL20 (F-box and leucine rich repeat protein 20).
WB Description
fbxl-1 encodes the sole C. elegans leucine-rich repeat (LRR)-type F-box protein that is equally related to mammalian FBXL2 and FBXL20; fbxl-1(RNAi) results in animals with altered defecation rhythm and decreased dauer formation upon treatment with dauer pheromone (daumone); an fbxl-1 promoter::gfp fusion is expressed in the anterior and posterior regions of the worm, specifically around the amphids and anal sphincter, respectively.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13318
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            8.2280M8.2285M8.2290M8.2295M8.2300M8.2305M8.2310M8.2315M8.2320M8.2325M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            fbxl-1 molecule type
            Interactor gene
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              Genetic Interactions

              fbxl-1 role
              fbxl-1 genetic perturbation
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