Version: 8.0.0Date: Tue Jan 28 2025
Gene
adah-1
- Species
- Caenorhabditis elegans
- Symbol
- adah-1
- Name
- Adenosine DeAminase Homolog 1
- Synonyms
- C06G3.5
- CELE_C06G3.5
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable adenosine deaminase activity. Predicted to be involved in hypoxanthine salvage; negative regulation of adenosine receptor signaling pathway; and purine ribonucleoside metabolic process. Predicted to be active in cytosol and external side of plasma membrane. Is expressed in several structures, including head mesodermal cell; nervous system; pharynx; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in asthma; colon cancer; pleural tuberculosis; severe combined immunodeficiency (multiple); and uterine fibroid. Orthologous to human ADA (adenosine deaminase).
- WB Description
- C06G3.5 is orthologous to human ADENOSINE DEAMINASE (ADA; OMIM:102700), which when mutated leads to severe combined immunodeficiency; in C. elegans, C06G3.5 is an essential gene; C06G3.5 is broadly expressed; about 2% to 6% of C06G3.5a transcripts are RNA edited to change A to G resulting in a change to residue 59 from a D to a G.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11409
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrIV:7024211...7028147 + (3.94 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction