Gene

mlst-8

Species
Caenorhabditis elegans
Symbol
mlst-8
Name
Mtor (MTOR) associated protein, LST8 homolog 8
Synonyms
  • C10H11.8
  • CELE_C10H11.8
Biotype
protein coding gene
Automated Description
Involved in mesendoderm development. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog).
WB Description
mlst-8 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of Saccharomyces cerevisiae and mammalian Lst8; by homology, MLST-8 is predicted to function as a member of the TOR complexes to regulate growth, development, and actin cytoskeleton organization; loss of mlst-8 activity via RNAi results in increased fat content, developmental delays, and small body size; RNAi targeting mlst-8 as well as let-502 results in defects in P cell migration.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR19842
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.7355M4.7360M4.7365M4.7370M4.7375M4.7380M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions