Version: 8.0.0
Date: Tue Jan 28 2025
erl-1
Caenorhabditis elegansWB:WBGene00016592
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

erl-1

Species
Caenorhabditis elegans
Symbol
erl-1
Name
ERLin (ER lipid raft associated protein) homolog 1
Synonyms
  • C42C1.15
  • CELE_C42C1.15
Biotype
protein coding gene
Automated Description
Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
WB Description
erl-1 encodes a protein of the prohibitin family and is orthologous to the human Erlin proteins, Erlin1 (KEO4) and Erlin2 (SPFH2), which are components of lipid rafts; human erlins have been implicated in negatively regulating IP3 receptors and other proteins through the endoplasmic reticulum-associated degradation (ERAD) pathway; in elegans, loss of erl-1 did not cause any obvious phenotype, did not seem to modulate the IP3 receptor, ITR-1, or ITR-1 dependent processes, like brood size, embryogenesis, or defecation rate; erl-1 did not affect the response to ER stress or play an essential role in the ERAD pathway; erl-1 is detected in the cytoplasm of early embryos, and in the gonad of adult worms.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15351
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            erl-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              erl-1 role
              erl-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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