Gene

bbs-9

Species
Caenorhabditis elegans
Symbol
bbs-9
Name
BBS (Bardet-Biedl Syndrome) protein 9
Synonyms
  • C48B6.8
  • CELE_C48B6.8
Biotype
protein coding gene
Automated Description
Predicted to be involved in cilium assembly. Located in ciliary basal body. Used to study Bardet-Biedl syndrome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 9; craniosynostosis; and primary ovarian insufficiency. Orthologous to human BBS9 (Bardet-Biedl syndrome 9).
WB Description
bbs-9 is orthologous to the human parathyroid hormone-responsive B1 gene, also known as BBS9; bbs-9 apart from being required for proper cilium morphology and function, is also required, similar to bbs-1, bbs-5, and bbs-8, for the regulation of insulin release from sensory neurons; bbs-9 mutants exhibit an increased secretion of insulin, daf-7, a neurally expressed TGF-beta ligand, and flp-21, a FRMF-amide neuropeptide; accordingly mutants display body size, feeding and metabolic defects; increased secretion of bbs mutants requires the Rab27/AEX-6 dense-core vesicle exocytosis machinery; the metabolic and ciliary phenotypes of bbs-9 and similar bbs mutants indicate that normal ciliary function is required for detection of food-related stimuli along with the coordination of metabolic, growth and insulin-signaling pathways.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR20991
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
6.9180M6.9185M6.9190M6.9195M6.9200M6.9205M6.9210M6.9215M6.9220M6.9225M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions