Gene

djr-1.2

Species
Caenorhabditis elegans
Symbol
djr-1.2
Name
DJ-1 (mammalian transcriptional regulator) Related 1.2
Synonyms
  • C49G7.11
  • CELE_C49G7.11
Biotype
protein coding gene
Automated Description
Predicted to enable glyoxalase III activity. Involved in several processes, including cellular response to aldehyde; glyoxal metabolic process; and monocarboxylic acid biosynthetic process. Located in cytoplasm. Is expressed in several structures, including excretory cell; nervous system; pharynx; rectum; and reproductive system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 7; Parkinsonism; cerebral infarction; and middle cerebral artery infarction. Orthologous to human PARK7 (Parkinsonism associated deglycase).
WB Description
djr-1.2 encodes a glyoxylase orthologous to human DJ-1; DJR-1.2 is expressed throughout the life cycle in a variety of tissues including pharyngeal muscles, the pharyngeal-intestinal valve, the ventral nerve cord, spermatheca, rectal gland cell, inner labial (IL) cells of head neurons, the phasmid (PHA/PHB) neurons, and supporting sheath/socket cells, and in adults is also found in the head mesodermal cell (HMC), excretory canals and coelomocytes; DJR-1.2 localizes to the cytosol.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48094
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.0541M4.0542M4.0543M4.0544M4.0545M4.0546M4.0547M4.0548M4.0549M4.0550M4.0551M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            djr-1.2 molecule type
            Interactor gene
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              Genetic Interactions

              djr-1.2 role
              djr-1.2 genetic perturbation
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