Gene

F09F7.5

Species
Caenorhabditis elegans
Symbol
F09F7.5
Name
CRIB domain-containing protein
Synonyms
  • CELE_F09F7.5
Biotype
protein coding gene
Automated Description
Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction and regulation of cell shape. Predicted to be located in cytoskeleton and plasma membrane. Orthologous to human CDC42SE1 (CDC42 small effector 1) and CDC42SE2 (CDC42 small effector 2).
WB Description
F09F7.5 encodes, by alternative splicing, three isoforms of an unfamiliar protein required for in conjunction with LIN-35 for normally large brood size, in conjunction with CLK-2 for normally rapid growth, and for normally short lifespan; F09F7.5 binds equally well to Cdc42 and Rac GTPases in vitro, probably through its N-terminal P21-Rho-binding domain; F09F7.5 has no obvious orthologs outside of Caenorhabditis species, and aside from its N-terminus is interspersed with low-complexity residues.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13502
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.5470M5.5475M5.5480M5.5485M5.5490M5.5495M5.5500M5.5505M5.5510M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            F09F7.5 molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              F09F7.5 role
              F09F7.5 genetic perturbation
              Interactor gene
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