Version: 8.0.0
Date: Tue Jan 28 2025
farl-11
Caenorhabditis elegansWB:WBGene00017349
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

farl-11

Species
Caenorhabditis elegans
Symbol
farl-11
Name
FAR (Factor ARrest) Like 11
Synonyms
  • CELE_F10E7.8
  • F10E7.8
Biotype
protein coding gene
Automated Description
Involved in endoplasmic reticulum organization; epithelial tube morphogenesis; and positive regulation of endocytic recycling. Located in endoplasmic reticulum. Is expressed in germ line. Orthologous to human STRIP1 (striatin interacting protein 1) and STRIP2 (striatin interacting protein 2).
WB Description
farl-11 is an ortholog of human STRIP2 (striatin interacting protein 2) and STRIP1 (striatin interacting protein 1); FARL-11 is required for normal ER dynamics and the membrane localization of GLP-1 in the germline; translation of farl-11 mRNA in the mitotic germline is promoted by PUF-8; FARL-11::GFP expressed under the endogenous promoter and 3' UTR localizes to endoplasmic reticulum and the nuclear membrane in the germline and embryos.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13239
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            7.1015M7.1020M7.1025M7.1030M7.1035M7.1040M7.1045M7.1050M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            farl-11 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              farl-11 role
              farl-11 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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