Gene

hmgs-1

Species
Caenorhabditis elegans
Symbol
hmgs-1
Name
HMG-CoA Synthase 1
Synonyms
  • CELE_F25B4.6
  • F25B4.6
Biotype
protein coding gene
Automated Description
Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2).
WB Description
F25B4.6 is orthologous to the human gene 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE (HMGCS2; OMIM:600234), which when mutated leads to disease.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43323
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.6828M5.6830M5.6832M5.6834M5.6836M5.6838M5.6840M5.6842M5.6844M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions