Gene

vpr-1

Species
Caenorhabditis elegans
Symbol
vpr-1
Name
VAP (VAMP-associated protein) Related 1
Synonyms
  • CELE_F33D11.11
  • F33D11.11
Biotype
protein coding gene
Automated Description
Enables ephrin receptor binding activity and protein domain specific binding activity. Predicted to be involved in endoplasmic reticulum membrane organization and endoplasmic reticulum-plasma membrane tethering. Predicted to be located in cytoskeleton and membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including body wall musculature; gonad; intestine; muscle cell; and nervous system. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPA (VAMP associated protein A) and VAPB (VAMP associated protein B and C).
WB Description
vpr-1 encodes the C. elegans VAP (VAMP-associated protein) ortholog, a transmembrane protein containing an N-terminal extracellular major sperm protein (MSP) domain; loss of vpr-1 function during development indicates that vpr-1 is required, both in vab-1-dependent and vab-1-independent pathways, for proper distal tip cell migration during somatic gonad development, ventral hypodermal cell migrations during embryonic enclosure, and anteriorly directed amphid neuron migration; like C. elegans MSPs, injection of the VPR-1 MSP domain into fog-2 females induces oocyte maturation and gonadal sheath cell contraction; the VPR-1 MSP domain directly binds the VAB-1/Ephrin receptor extracellular domain in vitro and in vivo, binds the oocyte and gonadal sheath cell plasma membranes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10809
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            5.8684M5.8686M5.8688M5.8690M5.8692M5.8694M5.8696M5.8698M

            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            vpr-1 molecule type
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              Genetic Interactions

              vpr-1 role
              vpr-1 genetic perturbation
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