Gene

F44E7.4

Species
Caenorhabditis elegans
Symbol
F44E7.4
Name
Insulin-degrading enzyme
Synonyms
  • CELE_F44E7.4
Biotype
protein coding gene
Automated Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis involved in protein catabolic process. Predicted to be active in cytosol and mitochondrion. Is expressed in gonad. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
WB Description
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide catabolic process and proteolysis involved in protein catabolic process. Predicted to be located in cytosol and mitochondrion. Expressed in gonad. Human ortholog(s) of this gene implicated in Alzheimer's disease; diabetic encephalopathy; and type 2 diabetes mellitus. Is an ortholog of human IDE (insulin degrading enzyme).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43690
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.7730M5.7735M5.7740M5.7745M5.7750M5.7755M5.7760M5.7765M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions