Gene

lin-42

Species
Caenorhabditis elegans
Symbol
lin-42
Name
abnormal cell LINeage 42
Synonyms
  • Cel-Mir-10-P3e
  • CELE_F47F6.1
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in negative regulation of dauer larval development; negative regulation of miRNA transcription; and regulation of development, heterochronic. Located in cytoplasm and nucleus. Is expressed in several structures, including H1L.app; H1R.app; H2L.ppp; hypodermal cell; and pharynx. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 1; alcohol dependence; cocaine dependence; and fetal alcohol spectrum disorder. Orthologous to human PER1 (period circadian regulator 1) and PER2 (period circadian regulator 2).
WB Description
lin-42 encodes three PAS domain-containing proteins orthologous to insect and vertebrate Period proteins that function in regulation of circadian rhythms; during larval development, lin-42 functions in the heterochronic pathway to regulate developmental switches that occurs in multiple tissues, including the hypodermis, gonad, sex myoblasts, and vulva; genetic analysis suggests that, in the hypodermis, lin-42 acts downstream of lin-46 and in the hypodermis and gonad, in parallel to daf-12 and upstream of lin-29; lin-42 mRNA levels oscillate during larval development with peak levels seen during intermolts and low levels seen during ecdysis and after the L4-to-adult molt; LIN-42 protein appears to be a widely expressed nuclear protein whose levels also fluctuate during larval stages, with peak protein typically seen towards the latter half of each larval stage in a cell type-specific manner, and then disappearing during each successive molt; in addition to three PAS domain-containing proteins, lin-42 also encodes a protein that lacks the PAS domain; transformation rescue experiments indicate that the LIN-42 isoform lacking the PAS domain is sufficient for rescue when present in multiple copies.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11269
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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1.234M1.236M1.238M1.240M1.242M1.244M1.246M1.248M1.250M1.252M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions