Gene

dgn-2

Species
Caenorhabditis elegans
Symbol
dgn-2
Name
DystroGlycaN 2
Synonyms
  • CELE_F56C3.6
  • F56C3.6
Biotype
protein coding gene
Automated Description
Predicted to enable laminin binding activity. Predicted to be involved in axon guidance; morphogenesis of an epithelium; and nerve development. Predicted to be located in membrane. Predicted to be part of dystroglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1).
WB Description
Predicted to enable laminin binding activity. Predicted to be involved in axon guidance; morphogenesis of an epithelium; and nerve development. Predicted to be located in sarcolemma. Predicted to be part of dystroglycan complex. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; Fukuyama congenital muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; bronchopulmonary dysplasia; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Is an ortholog of human DAG1 (dystroglycan 1).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21559
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            1.3656M1.3658M1.3660M1.3662M1.3664M1.3666M1.3668M1.3670M1.3672M1.3674M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            dgn-2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              dgn-2 role
              dgn-2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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