Version: 8.0.0
Date: Tue Jan 28 2025
ccpp-1
Caenorhabditis elegansWB:WBGene00018995
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ccpp-1

Species
Caenorhabditis elegans
Symbol
ccpp-1
Name
Cytosolic CarboxyPePtidase family 1
Synonyms
  • CELE_F56H1.5
  • F56H1.5
Biotype
protein coding gene
Automated Description
Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Involved in egg-laying behavior. Predicted to be located in cilium; dendrite; and perikaryon. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in gubernacular muscle and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to several human genes including AGBL1 (AGBL carboxypeptidase 1).
WB Description
ccpp-1 encodes a putative ATP/ADP-activated metallocarboxypeptidase that may function in vivo as an alpha-tubulin C-terminal tyrosine carboxypeptidase; CCPP-1 is orthologous to murine AGTPBP-1/Nna1/pcd (upregulated in damaged mouse spinal cord and mutated in Purkinje cell degeneration) and human AGTPBP1 (OMIM:606830); murine AGTPBP-1 is genetically required for tubulin carboxypeptidase activity in vivo, and CCPP-1's nearest paralog CCPP-6 has biochemical traits consistent with tubulin carboxypeptidase activity; CCPP-1 and its mammalian AGTPBP1 orthologs, along with other proteins, comprise a M14D3 peptidase subfamily.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12756
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            5.755M5.756M5.757M5.758M5.759M5.760M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ccpp-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              ccpp-1 role
              ccpp-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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