Gene

tat-2

Species
Caenorhabditis elegans
Symbol
tat-2
Name
Transbilayer Amphipath Transporters (subfamily IV P-type ATPase) 2
Synonyms
  • CELE_H06H21.10
  • H06H21.10
Biotype
protein coding gene
Automated Description
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Involved in sterol metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane and trans-Golgi network. Is expressed in several structures, including excretory system; gonad; pharynx; rectal gland cell; and vulva. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to several human genes including ATP8B4 (ATPase phospholipid transporting 8B4 (putative)).
WB Description
tat-2 encodes one of six C. elegans subfamily IV P-type ATPase that, by sequence similarity, is proposed to function as an aminophospholipid translocase (flippase); genetic analyses show that tat-2 has two distinct functions in lipid metabolism: 1) tat-2 is essential for reproductive growth under conditions of sterol deprivation, and 2) TAT-2 activity in the intestine plays a role in regulating monomethyl branched-chain fatty acid-mediated functions during postembryonic growth and development; a tat-2::gfp promoter fusion is expressed beginning at the two-fold stage of embryogenesis and continuing through adulthood with expression detected in pharyngeal cells, the intestine, rectal gland cells, the excretory system, the primary vulval lineages, and the gonad.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24092
No data available
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Paralogy

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            4.828M4.830M4.832M4.834M4.836M4.838M4.840M4.842M4.844M4.846M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            tat-2 molecule type
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              Genetic Interactions

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              tat-2 genetic perturbation
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