Version: 8.0.0
Date: Tue Jan 28 2025
zmp-2
Caenorhabditis elegansWB:WBGene00019212
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

zmp-2

Species
Caenorhabditis elegans
Symbol
zmp-2
Name
Zinc MetalloProtease 2
Synonyms
  • CELE_H19M22.3
  • H19M22.3
Biotype
protein coding gene
Automated Description
Enables metallopeptidase activity. Involved in several processes, including determination of adult lifespan; ecdysis, collagen and cuticulin-based cuticle; and negative regulation of metabolic process. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including RME; anal region; gonad; tail; and vulval muscle. Orthologous to human MMP23B (matrix metallopeptidase 23B).
WB Description
Enables metallopeptidase activity. Involved in several processes, including regulation of metabolic process; regulation of transport; and response to stress. Predicted to be located in extracellular space. Expressed in several structures, including anal region; body wall musculature; gonad; tail; and vulval muscle. Is an ortholog of human MMP23B (matrix metallopeptidase 23B).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10201
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            2.637M2.638M2.639M2.640M2.641M2.642M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            zmp-2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              zmp-2 role
              zmp-2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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