Gene

cogc-8

Species
Caenorhabditis elegans
Symbol
cogc-8
Name
Conserved Oligomeric Golgi (COG) Component 8
Synonyms
  • CELE_R02D3.2
  • R02D3.2
Biotype
protein coding gene
Automated Description
Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIh. Orthologous to human COG8 (component of oligomeric golgi complex 8).
WB Description
cogc-8 encodes an ortholog of mammalian COG-8, a subunit of lobe B ofthe conserved oligomeric Golgi complex (COGC); COGC-8 is weakly requiredfor normal gonadal distal tip cell migration, a process that alsorequires seven other orthologs of COGC subunits; like other lobe Bsubunits in both C. elegans and S. cerevisiae, COGC-8 is only partiallyrequired for normal function, while lobe A subunits are stronglyrequired in either worms or yeast.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21311
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            240.5k241.0k241.5k242.0k242.5k243.0k243.5k244.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cogc-8 molecule type
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              Genetic Interactions

              cogc-8 role
              cogc-8 genetic perturbation
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